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Scrivener Publishing
100 Cummings Center, Suite 541J
Beverly, MA 01915-6106

Advanced Materials Series
The Advanced Materials Series provides recent advancements of the fascinating field of advanced materials science and technology, particularly in the area of structure, synthesis and processing, characterization, advanced-state properties, and applications. The volumes will cover theoretical and experimental approaches of molecular device materials, biomimetic materials, hybrid-type composite materials, functionalized polymers, supramolecular systems, information- and energy-transfer materials, biobased and biodegradable or environmental friendly materials. Each volume will be devoted to one broad subject and the multidisciplinary aspects will be drawn out in full.

Series Editor: Ashutosh Tiwari
Biosensors and Bioelectronics Centre
Linköping University
SE-581 83 Linköping
Sweden
E-mail: ashutosh.tiwari@liu.se

Managing Editors: Sachin Mishra and Sophie Thompson

Publishers at Scrivener
Martin Scrivener (martin@scrivenerpublishing.com)
Phillip Carmical (pcarmical@scrivenerpublishing.com)

Advanced Surfaces for Stem Cell Research

 

 

 

 

Edited by

Ashutosh Tiwari

Bora Garipcan

Lokman Uzun

 

 

 

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Preface

Stem cells have attracted much attention in the fields of regenerative medicine and tissue engineering for their important role in the treatment of several diseases. This is due to their unique properties such as their self-renewal capability and ability to differentiate into specific cell types. New research and therapies in these fields are mainly focused on a better understanding of the natural mechanisms of stem cells and the control and regulation of their behavior under in-vivo or in-vitro conditions. Since a natural and/or synthetic surface is an important physical structure for most of the cells, the effect of surface properties, such as chemistry, charge, energy, hydropathy, pattern, topography, and stiffness, with or without differentiation media, influences stem cell behavior as well as controls and directs stem cell differentiation. Biomaterials that are developed by altering surface properties are a promising challenge for regenerative medicine and tissue engineering fields, drug investigation/toxicity studies and stem cell-based therapies.

This book, Advanced Surfaces in Stem Cell Research, part of the Advanced Materials Series, first outlines the importance of extra cellular matrix (ECM), which is a natural surface for most cells, and is discussed in the first chapter entitled “Extracellular Matrix Proteins for Stem Cell Fate.” Chapters 2 through 6 discuss the influence of biological, chemical, mechanical, and physical properties on stem cell behavior and fate. The mechanical and physical properties of matrix microenvironment as stem cell fate regulator are reviewed in Chapter 2, followed by a discussion on the effect of mechanotransduction on stem cell behavior in chapter 3. In chapter 4, stem cell modulation on bioactive surfaces is disputed. Since micro- and nanoscale structure and surfaces have an influence on stem cell behavior and fate, these properties are discussed in chapters 5 and 6, respectively entitled “Influence of Controlled Micro- and Nano-Engineered Surfaces on Stem Cell Fate” and “Recent Advances in Nanostructured Polymeric Surface: Challenges and Frontiers in Stem Cells.” Chapters 7 through 10 deliberate 2D and 3D surface fabrication and modification using different techniques on stem cell fate. Laser surface modification techniques and stem cell applications and plasma polymer deposition as a versatile tool for stem cell research are discussed in chapters 7 and 8, respectively. The effect of 3D structures and dynamic cell environment, such as bioreactors, on stem cell fate are presented in detail in chapters 9 and 10, respectively entitled “3D Printing Approaches for the Treatment of Critical-Sized Bone Defect” and “Application of Bioreactor Concept and Modeling Techniques in Bone Regeneration and Augmentation Treatments.” Chapter 11 is an important and interesting chapter which will inform readers from a different point of view, with regulatory perspectives on medical products as stem cell-based medicinal products. One of the recent stem cell sources, pluripotent stem cells, are discussed in chapter 12, “Substrates and Surfaces for Control of Pluripotent Stem Cell Fate and Function.” Surface engineering applications are discussed in tissue engineering, regenerative medicine and different types of biomaterials in chapters 13 and 14, respectively entitled “Silk as a Natural Biopolymer for Tissue Engineering” and “Application of Biopolymer-Based, Surface Modified Devices in Transplant Medicine and Tissue Engineering.” Biomimetic and bioinspired approaches are also indicated for developing microenvironment of several tissues in chapter 15, “Stem Cell Behavior on Microenvironment Mimicked Surfaces.”

We would like to thank the authors that have contributed to the chapters of this book, including all scientists who have contributed to this topic. We hope and believe that this book will be very useful to those in the biomaterials, tissue engineering, regenerative medicine, stem cell research and material science communities.

Editors
Ashutosh Tiwari, PhD, DSc
Bora Garipcan, PhD
Lokman Uzun, PhD
September 2016